Welcome to the Pletzer Lab We combat infectious diseases and develop strategies to reduce antimicrobial resistance Read More Join the lab to learn more about Infectious Diseases and novel treatment strategies Read More Contact Us
University-of-Otago_600
Welcome to the Pletzer Lab

Dr Daniel Pletzer established his laboratory in 2019 in the Microbiology & Immunology Department at the University of Otago in Dunedin in the South Island of beautiful New Zealand.

Dr Daniel Pletzer

Principal Investigator

Pletzer Lab

2022

Explore our Research Topics

image-box
Antimicrobial Resistance

We explore alternative ways to treat multidrug resistant pathogens.

image-box
Infectious Diseases

We investigate complex infections to understand disease causing mechanisms.

image-box
Bioinformatics and Computational Biology

We use high-throughput sequencing to unravel novel host-pathogen interactions.

Understand how microbes cause disease

Our research focuses to understand how microorganisms cause disease and what mechanisms they employ to overcome environmental stress. Of particular interest are polymicrobial infections (two or more microbes occupying the same niche) and how multiple microbes can change the course of infection and treatment. To accomplish this, we investigate host-pathogen interactions in culture conditions and in the context of complex skin infections such as abscesses and wounds.

Our research examines a variety of important nosocomial organisms including all of the so-called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species ) as well as Escherichia coli, Cutibacterium acnes  and Streptococcus pyogenes.

Fight antimicrobial resistance

Antibiotics are arguably the most important and successful medicines. However, the frequent growth of bacteria as biofilms, which are bacterial communities that grow in a protective matrix, is of great concern. Biofilm-associated infections (for example found in the cystic fibrosis lung or in chronic infections) are particularly difficult to treat with conventional antibiotics since bacteria growing within biofilms can be up to 1000-fold more resistant to antibiotics. This type of resistance is termed adaptive resistance and has been proposed to play a major role in reducing the therapeutic effectiveness of antimicrobial compounds.

Currently, there is no specific treatment for such infections. The biofilm lifestyle is also associated with chronic infections predominantly caused by multiple bacterial species occupying the same infection site. We are therefore interested in how polymicrobial biofilms form during disease and what makes them so recalcitrant towards antibiotic treatment.

Develop novel antimicrobial strategies

We have developed a murine skin infection model that forms the basis for the development and investigation of novel therapeutics to address the global problem of antimicrobial resistance to improve health and treatment. We are interested in compounds that exhibit broad-spectrum activity towards bacterial biofilms and/or work by neutralizing bacterial infection strategies rather than just killing them.

The lab also works on strategies to overcome bacterial resistance mechanisms by developing antibiotic-conjugates that increase the uptake efficiency of already approved drugs.

WHO-priority pathogens to discover new mechanisms to overcome multidrug resistance

Our focus is on the so-called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) as they are the leading cause of hospital-acquired infections worldwide.

Our lab covers a broad range of expertise
  • Microbiology
  • Immunology
  • Bioinformatics
  • Chronic infections
  • High density infections
  • Skin & lung disease
Antibiotic resistance New Zealand

The Pletzer Lab is located at the University of Otago.

Explore our world-class research

From Microbiology & Immunology to Virology & Parasitology

Follow Daniel Pletzer and the Lab on Twitter

our multidisciplinary centre brings together an exciting team of scientists and clinicians from across Aotearoa New Zealand to tackle this worldwide threat.
@jlot006 @DrH_aucklanduni @pletzerlab @shotliverfreak @UniServicesNZ @BashiriLab (3/3)

Why are some groups of bacteria so good at being host associated? A new paper from our lab @ISMEJournal shows that a conserved two-component signalling pathway ColR/S is required for plant and animal association in diverse Pseudomonas species. 1/4 https://rdcu.be/c0kw9

Congratulations to Professor Gregory Cook, Professor Keith Ireton, and Dr Daniel Pletzer for being awarded Royal Society of New Zealand Marsden grants!
Check out the full list of recipients below:
https://www.otago.ac.nz/news/news/releases/otago0235933.html

JB Editor's Pic: Pseudomonas can kill Staph aureus under certain conditions. Here the authors show another mechanism whereby these two bacteria can co-exist - Staph can produce molecules that antagonize Pseudomonas
https://journals.asm.org/doi/10.1128/jb.00174-22
@ASMicrobiology @JBacteriology

Load More
Contact Daniel Pletzer via the Department

Phone: +64 3 479 7734 (Microbiology & Immunology)

Drop an email to Daniel Pletzer

pletzerlab(at)gmail.com

Where to find the Pletzer Lab

720 Cumberland Street, 9054 Dunedin, New Zealand