Explore Research in the Pletzer Lab ...
Our research examines a variety of important nosocomial organisms including all of the so-called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species ) as well as Escherichia coli, Cutibacterium acnes and Streptococcus pyogenes.
Currently, there is no specific treatment for such infections. The biofilm lifestyle is also associated with chronic infections predominantly caused by multiple bacterial species occupying the same infection site. We are therefore interested in how polymicrobial biofilms form during disease and what makes them so recalcitrant towards antibiotic treatment.
The lab also works on strategies to overcome bacterial resistance mechanisms by developing antibiotic-conjugates that increase the uptake efficiency of already approved drugs.
About the Pletzer Laboratory
We are located in Dunedin in the South Island of beautiful New Zealand. The lab was established in 2019 at the University of Otago.