Featured publication

The stringent stress response controls proteases and global regulators under optimal growth conditions in Pseudomonas aeruginosa

Pletzer D, Blimkie TM, Wolfmeier H, Li Y, Baghela A, Lee AHY, Falsafi R, Hancock REW. mSystems. 05 August 2020


—– 2020 —–

  1. Copp JN, Pletzer D, Brown AS, Van der Heijden J, Miton CM, Edgar RJ, Rich MH, Little RF, Williams EM, Hancock REW, Tokuriki N, Ackerley DF.  2020. Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections. mBio. 10.1128/mBio.02068-20
  2. Khomtchouk KM, Kouhi A, Xia A, Bekale LA, Massa SM, Sweere JM, Pletzer D, Hancock REW, Bollyky PL, Santa Maria PL.  2020. A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation. Sci Adv. 10.1126/sciadv.abc1828
  3. Etayash H, Pletzer D, Kumar P, Straus SK, Hancock REW.  2020. A cyclic derivative of host-defence peptide IDR-1018 improves proteolytic stability, suppresses inflammation, and enhances in vivo activity. J Med Chem. 10.1021/acs.jmedchem.0c00303
  4. Pletzer D, Blimkie TM, Wolfmeier H, Li Y, Baghela A, Lee AHY, Falsafi R, Hancock REW.  2020. The stringent stress response controls proteases and global regulators under optimal growth conditions in Pseudomonas aeruginosa. mSystems. 10.1128/mSystems.00495-20
  5. Moosavian M, Emam N, Pletzer D, Savari M.  2020. Rough-type and loss of the LPS due to lpx genes deletions are associated with colistin resistance in multidrug-resistant clinical Escherichia coli isolates not harbouring mcr genes. PLoS One. 10.1371/journal.pone.0233518
  6. Alford MA, Baghela A, Yeung ATY, Pletzer D, Hancock REW.  2020. NtrBC regulates invasiveness and virulence of Pseudomonas aeruginosa during high-density infection. Front Microbiol. 10.3389/fmicb.2020.00773
  7. Pletzer D*, Sun E*, Ritchie C, Wilkinson L, Liu LT, Trimble MJ, Wolfmeier H, Blimkie TM, Hancock REW. 2020. Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58. PLOS Pathog. 10.1371/journal.ppat.1008444

—– 2019 —–

  1. Woehlk H, Trimble M, Mansour S, Pletzer D, Trouillet V, Welle A, Barner L, Hancock REW, Barner-Kowollik C, Fairfull-Smith K. 2019. Controlling biofilm formation with nitroxide functional surfaces. Polym Chem. 10.1039/C9PY00690G
  2. Kłodzińska SN, Pletzer D, Rahanjam N, Rades T, Hancock REW, Nielsen HM. 2019. Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5. Nanomedicine. 10.1016/j.nano.2019.102022
  3. Alford MA*, Pletzer D*, Hancock REW. 2019. Dismantling the bacterial virulence program. Microb Biotechnol. 10.1111/1751-7915.13388

—– 2018 —–

  1. Kumar P*, Pletzer D*, Haney EF, Rahanjam N, Cheng JTJ, Yue M, Aljehani W, Hancock REW, Kizhakkedathu JN, Straus SK. 2018. Aurein-derived antimicrobial peptides formulated with pegylated phospholipid micelles to target methicillin-resistant S. aureus skin infections. ACS Infect Dis. 10.1021/acsinfecdis.8b00319 
  2. Pletzer D, Hancock REW. 2018. Is synergy the key to treating high-density infections?. Future Microbiol. 13:1629-1632 
  3. Wolfmeier H, Mansour SC, Liu LT, Pletzer D, Draeger A, Babiychuk EB, Hancock REW. 2018. Liposomal therapy attenuates dermonecrosis induced by community-associated methicillin-resistant Staphylococcus aureus by targeting alpha-type phenol-soluble modulins and alpha-hemolysin. EBioMedicine. 33:211-217 
  4. Pletzer D, Mansour SC, Hancock REW. 2018. Synergy between conventional antibiotics and antibiofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens. PLoS Pathog. 14(6):e1007084 
  5. Windham IH, Servetas SL, Whitmire JM, Pletzer D, Hancock REW, Merrell SD. 2018Helicobacter pylori biofilm formation is differentially affected by common culture conditions, and proteins play a central role in the biofilm matrix. Appl Environ Microbiol. 84(14). pii: e00391-18 
  6. Luscher A, Moynie L, Auguste PS, Bumann D, Mazza L, Pletzer D, Naismith J, Koehler T. 2018. TonB-dependent receptor repertoire of Pseudomonas aeruginosafor uptake of siderophore-drug conjugates. Antimicrob Agents Chemother. 62(6). pii: e00097-18 
  7. Haney EF*, Pletzer D*, Hancock REW. 2018. Impact of host defence peptides on chronic wounds and infections. Title of book: Recent clinical techniques, results, and research in wounds. Editors: Melvin A. Shiffman, Mervin Low. Springer, Cham. 1-17

—– 2017 —–

  1. Wolfmeier H*, Pletzer D*, Mansour SC*, Hancock REW. 2017. New perspectives in biofilm eradication. ACS Infect Dis. 4(2):93-106 
  2. Pletzer D, Wolfmeier H, Bains M, Hancock REW. 2017. Synthetic peptides target stringent response-controlled virulence in a Pseudomonas aeruginosa murine cutaneous infection model. Front Microbiol. 8:1867 
  3. Belanger C*, Mansour SC*, Pletzer D*, Hancock REW. 2017. Alternative strategies for the study and treatment of clinical bacterial biofilms. Emerg Top Life Sci. ETLS20160020 
  4. Pothula KR, Dhanasekar NN, Lamichhane U, Younas F, Pletzer D, Benz R, Winterhalter M, Kleinekathoefer U. 2017. Single residue acts as gate in OccK channels. J Phys Chem B. 121(12):2614-2621 
  5. Pletzer D, Mansour SC, Rahanjam N, Wuerth K, Hancock REW. 2017. New mouse model for chronic infections by Gram-negative bacteria enabling the study of anti-infective efficacy and host-microbe interactions. mBio.
  6. Moynie L, Luscher A, Rolo D, Pletzer D, Tortajada A, Weingart H, Braun Y, Page MG, Naismith JH, Koehler T. 2017. Structure and function of the PiuA and PirA siderophore-drug receptors from P. aeruginosa and A. baumanniiAntimicrob Agents Chemother. 61(4). pii: e02531-16 
  7. Chalhoub H, Pletzer D, Weingart H, Braun Y, Tunney MM, Elborn JS, Rodriguez-Villalobos H, Plesiat P, Kahl BC, Denis O, Winterhalter M, Tulkens PM, Van Bambeke F. 2017. Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic. Sci Rep. 7:40208 

—– 2016 —–

  1. Abdallah K, Hartman K, Pletzer D, Zhurina D, Ullrich MS. 2016. The bacteriophage-derived transcriptional regulator, LscR, activates the expression of levansucrase genes in Pseudomonas syringaeMol Microbiol. 102(6):1062-1074 
  2. Mansour SC, Pletzer D, de la Fuente-Nunez C, Kim P, Cheung GY, Joo HS, Otto M, Hancock REW. 2016. Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically. EBioMedicine. 12:219-226 
  3. Pletzer D, Hancock REW. 2016. Antibiofilm peptides: Potential as broad-spectrum agents. J Bacteriol. 198(19):2572-2578 
  4. Pletzer D*, Coleman SR*, Hancock REW. 2016. Anti-biofilm peptides as a new weapon in antimicrobial warfare. Curr Opin Microbiol. 33:35-40 
  5. Ganguly S, Jimenez-Galisteo G, Pletzer D, Winterhalter M, Benz R, Vienas M. 2016. Draft genome sequence of Dietza maris DSM 43672, a Gram+ bacterium of Mycolata group. Genome Announc. 4(3) 
  6. Pletzer D, Braun Y, Weingart H. 2016. Swarming motility is modulated by expression of the putative xenosiderophore transporter SppR-SppABCD in Pseudomonas aeruginosa PA14. Antonie Van Leeuwenhoek. 109(6):737-753 

—– 2015 —–

  1. Stahl A, Pletzer D, Mehmood A, Ullrich MS. 2015. Marinobacter adhaerens HP15 harbors two CzcCBA efflux pumps involved in zinc detoxification. Antonie Van Leeuwenhoek. 108(3):649-658 
  2. Pletzer D, Braun Y, Dubiley S, Lafon C, Koehler T, Page MG, Mourez M, Severinov K, Weingart H. 2015. The Pseudomonas aeruginosa PA14 ABC transporter NppA1A2BCD is required for uptake of peptidyl nucleoside antibiotics. J Bacteriol. 197(13):2217-2228 
  3. Mehmood A, Abdallah K, Khandekar S, Zhurina D, Srivastava A, Al-Karablieh N, Alfaro-Espinoza G, Pletzer D, Ullrich MS. 2015. Expression of extra-cellular levansucrase in Pseudomonas syringae is controlled by the in planta fitness-promoting metabolic repressor HexR. BMC Microbiol. 15:48 
  4. Pletzer D, Stahl A, Oja AE, Weingart H. 2015. Role of the cell envelope stress regulators BaeR and CpxR in control of RND-type multidrug efflux pumps and transcriptional cross talk with exopolysaccharide synthesis in Erwinia amylovoraArch Microbiol. 197(6):761-772 

—– 2014 —–

  1. Elsadig Karar MG, Pletzer D, Jaiswal R, Weingart H, Kuhnert N. 2014. Identification, characterization, isolation and activity against Escherichia coli of quince (Cydonia oblonga) fruit polyphenols. Food Res Int. Vol 65, Part A 121-129 
  2. Pletzer D, Lafon C, Braun Y, Koehler T, Page MG, Mourez M, Weingart H. 2014. High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate binding proteins DppA1-A5 in Pseudomonas aeruginosa. PLoS One. 9(10):e111311 
  3. Johnston C, Bannantine JP, Govender R, Endersen L, Pletzer D, Weingart H, Coffey A, O’Mahony J, Sleator RD. 2014. Enhanced expression of codon optimized Mycobacterium avium subsp. paratuberculosis antigens in Lactobacillus salivariusFront Cell Infect Microbiol. 4:120 
  4. Pletzer D, Schweizer G, Weingart H. 2014. AraC/XylS family stress response regulators Rob, SoxS, PliA, and OpiA in the fire blight pathogen Erwinia amylovoraJ Bacteriol. 196:3098-3110 
  5. Pletzer D, Weingart H. 2014. Characterization and regulation of the Resistance-Nodulation-Cell Division-type multidrug efflux pumps MdtABC and MdtUVW from the fire blight pathogen Erwinia amylovoraBMC Microbiol. 14:185 
  6. Khandekar S, Srivastava A, Pletzer D, Stahl A, Ullrich MS. 2014. The conserved upstream region of lscB/C determines expression of different levansucrase genes in plant pathogen Pseudomonas syringaeBMC Microbiol. 14:79 
  7. Pletzer D, Weingart H. 2014. Characterization of AcrD, a Resistance Nodulation-Cell Division-type multidrug efflux pump from the fire blight pathogen Erwinia amylovora. BMC Microbiol. 14:13

—– 2013 —–

  1. Johnston C, Douarre PE, Soulimane T, Pletzer D, Weingart H, MacSharry J, Coffey A, Sleator, RD, O’Mahony J. 2013. Codon optimisation to improve expression of a MAP-specific membrane-associated antigen by Lactobacillus salivariusPathog Dis. 68:27-38 

—– 2009 —–

  1. Veyrier F, Pletzer D, Turenne C, Behr MA. 2009. Phylogenetic detection of horizontal gene transfer during the step-wise genesis of Mycobacterium tuberculosisBMC Evol Biol. 9:196