Publications from the Pletzer lab Find out more about our recent publications ... .... just send us an email and we will send you a copy of the paper Contact us Friends or enemies? The complicated relationship between Pseudomonas aeruginosa and Staphylococcus aureus Yung DBY, Sircombe KJ, and Pletzer D. Molecular Microbiology. 12 February 2021 Enzymatically releasable polyethylene glycol – Host defense peptide conjugates with improved activity and biocompatibility Drayton M, Alford MA, Pletzer D, Haney E, Machado Y, Luo H, Overall C, Kizhakkedathu J, Hancock REW, Straus SK. Oct. 2021 Rapid microwave-based method for the preparation of antimicrobial lignin-capped silver nanoparticles active against multidrug-resistant bacteria Pletzer D, Asnis J, Slavin YN, Hancock REW, Bach H, Saatchi K, Haefeli UO. Jan. 2021.

2022

60. Targeting the Pseudomonas aeruginosa virulence factor phospholipase C with engineered liposomes.

Wolfmeier H, Wardell SJT, Liu LT, Falsafi R, Draeger A, Babiychuk EB, Pletzer D, Hancock REW

Front Microbiol

10.3389/fmicb.2022.867449

 

59. Self-assembly of antimicrobial peptoids impacts their biological effects on ESKAPE bacterial pathogens.

Nielsen J*, Alford MA*, Yung DBY*, Molchanova N, Fortkort J, Lin J, Diamond G, Hancock REW, Jenssen H, Pletzer D, Lund R, Barron A.

ACS Infect Dis.

10.1021/acsinfecdis.1c00536

 

58. Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures.

Gonçalves da Costa Sousa M, Conceição de Almeida G, Martins Mota DC, Andrade da Costa R, Dias SC, Limberger SN, Ko F, Lin LT, Haney EF, Etayash H, Baquir B, Trimble MJ, Shen Y, Su Z, Haapasalo M, Pletzer D, Chaves de Souza L, Schuindt Teixeira G, Silva RM, Hancock REW, Franco OL, Berto Rezende TM.

Bioact. Mater.

10.1016/j.bioactmat.2022.01.027

 

57. Ultraviolet-C irradiation, heat, and storage as potential methods of inactivating SARS-CoV-2 and bacterial pathogens on filtering facepiece respirators.

Harfoot R, Yung DBY, Anderson WA, Wild CEK, Coetzee N, Hernández LC, Lawley B, Pletzer D, Derraik JGB, Anderson YC, Quiñones-Mateu ME.

Pathogens.

10.3390/pathogens11010083

 

2021

56. 3D printed cellulose based product applications.

Firmanda A, Syamsu K, Sari WY, Cabral J, Pletzer D, Mahadikd B, Fisherd J, Fahma F.

Mater Chem Front.

10.1039/D1QM00390A

 

55. Enzymatically releasable polyethylene glycol – host defense peptide conjugates with improved activity and biocompatibility

Drayton M, Alford MA, Pletzer D, Haney E, Machado Y, Luo H, Overall C, Kizhakkedathu J, Hancock REW, Straus SK. 

J Control Release.

10.1016/j.jconrel.2021.09.035

 

54. Treatment with a neutrophil elastase inhibitor and ofloxacin reduces Pseudomonas aeruginosa burden in a mouse model of chronic suppurative otitis media.

Khomtchouk KM, Joseph LI, Khomtchouk BB, Kouhi A, Massa S, Xia A, Koliesnik I, Pletzer D, Bollyky PL, Santa Maria PL.

NPJ Biofilms Microbiomes. 10.1038/s41522-021-00200-z

 

53. Synergistic bactericidal activities of tobramycin with ciprofloxacin and azithromycin against Klebsiella pneumoniae.

Ren H, Zhang J, Zhou J, Xu C, Fan Z, Pan X, Li S, Liang Y, Chen S, Xu J, Wang P, Zhang Y, Zhu G, Liu H, Jin Y, Bai F, Cheng Z, Pletzer D, Wu W.

J Antibio (Tokyo). 10.1038/s41429-021-00427-0

 

 

52. Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa.

Wilkinson LV, Alford MA, Coleman SR, Wu BC, Lee AHY, Blimkie TM, Bains M, Falsafi R, Pletzer D, Hancock REW.

PLoS One. 10.1371/journal.pone.0250977

 

 

51. Friends or enemies? The complicated relationship between Pseudomonas aeruginosa and Staphylococcus aureus.

Yung DBY, Sircombe KJ, Pletzer D.

Mol Microbiol. 10.1111/mmi.14699

 

 

50. Murine models of sinusitis infection for screening antimicrobial and immunomodulatory therapies.

Alford MA, Choi KG, Trimble MJ, Masoudi H, Kalsi P, Pletzer D, Hancock REW.

Front Cell Infect Microbiol. 10.3389/fcimb.2021.621081

 

 

49. Rapid microwave-based method for the preparation of antimicrobial lignin-capped silver nanoparticles active against multidrug-resistant bacteria.

Pletzer D, Asnis J, Slavin YN, Hancock REW, Bach H, Saatchi K, Haefeli UO.

Int J Pharm. 10.1016/j.ijpharm.2021.120299

 

 

48. Towards understanding single-channel characteristics of OccK8 directly purified from Pseudomonas aeruginosa.

Guzel FD, Pletzer D, Dizaji AN, Al-Nahas K, Bajrai M, Winterhalter M.

Eur Biophys J. 10.1007/s00249-021-01498-5

 

 

2020

47. Contribution of swarming motility to dissemination in a Pseudomonas aeruginosa murine skin abscess infection model.

Coleman SR, Pletzer D, Hancock REW.

J Infect Dis. 10.1093/infdis/jiaa778

 

 

46. Human organoid biofilm model for assessing antibiofilm activity of novel agents.

Wu B, Haney EF, Akhoundsadegh N, Pletzer D, Trimble M, Adriaans AE, Nibbering PH, Hancock REW.

NPJ Biofilms Microbiomes. s41522-020-00182-4

 

 

45. Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media.

Belanger CR, Lee AHY, Pletzer D, Dhillon BK, Falsafi R, Hancock REW.

Proc Natl Acad Sci. 10.1073/pnas.2007626117

 

 

44. Host defense peptide-mimicking amphiphilic β-peptide polymer (Bu:DM) exhibiting anti-biofilm, immunomodulatory, and in vivo anti-infective activity.

Etayash H*, Qian *Y, Pletzer D*, Zhang Q*, Xie J, Cui R, Dai C, Ma P, Qi F, Liu R, Hancock REW.

J Med Chem. 10.1021/acs.jmedchem.0c01321

 

 

43. Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections.

Copp JN, Pletzer D, Brown AS, Van der Heijden J, Miton CM, Edgar RJ, Rich MH, Little RF, Williams EM, Hancock REW, Tokuriki N, Ackerley DF.

mBio. 10.1128/mBio.02068-20

 

 

42. A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation.

Khomtchouk KM, Kouhi A, Xia A, Bekale LA, Massa SM, Sweere JM, Pletzer D, Hancock REW, Bollyky PL, Santa Maria PL.

Sci Adv. 10.1126/sciadv.abc1828

 

 

41. A cyclic derivative of host-defence peptide IDR-1018 improves proteolytic stability, suppresses inflammation, and enhances in vivo activity.

Etayash H, Pletzer D, Kumar P, Straus SK, Hancock REW.

J Med Chem. 10.1021/acs.jmedchem.0c00303

 

 

40. The stringent stress response controls proteases and global regulators under optimal growth conditions in Pseudomonas aeruginosa.

Pletzer D, Blimkie TM, Wolfmeier H, Li Y, Baghela A, Lee AHY, Falsafi R, Hancock REW.

mSystems. 10.1128/mSystems.00495-20

 

 

39. Rough-type and loss of the LPS due to lpx genes deletions are associated with colistin resistance in multidrug-resistant clinical Escherichia coli isolates not harbouring mcr genes.

Moosavian M, Emam N, Pletzer D, Savari M.

PLoS One. 10.1371/journal.pone.0233518

 

 

38. NtrBC regulates invasiveness and virulence of Pseudomonas aeruginosa during high-density infection.

Alford MA, Baghela A, Yeung ATY, Pletzer D, Hancock REW.

Front Microbiol. 10.3389/fmicb.2020.00773/span>

 

 

37. Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58.

Pletzer D*, Sun E*, Ritchie C, Wilkinson L, Liu LT, Trimble MJ, Wolfmeier H, Blimkie TM, Hancock REW. 

PLoS Pathog. 10.1371/journal.ppat.1008444

 

 

2019

36. Controlling biofilm formation with nitroxide functional surfaces.

Woehlk H, Trimble M, Mansour S, Pletzer D, Trouillet V, Welle A, Barner L, Hancock REW, Barner-Kowollik C, Fairfull-Smith K. 

Polym Chem. 10.1039/C9PY00690G

 

 

35. Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5.

Kłodzińska SN, Pletzer D, Rahanjam N, Rades T, Hancock REW, Nielsen HM. 

Nanomedicine. 10.1016/j.nano.2019.102022

 

 

34. Dismantling the bacterial virulence program.

Alford MA*, Pletzer D*, Hancock REW. 

Microb Biotechnol. 10.1111/1751-7915.13388

 

 

2018

33. Aurein-derived antimicrobial peptides formulated with pegylated phospholipid micelles to target methicillin-resistant S. aureus skin infections.

Kumar P*, Pletzer D*, Haney EF, Rahanjam N, Cheng JTJ, Yue M, Aljehani W, Hancock REW, Kizhakkedathu JN, Straus SK. 

ACS Infect Dis. 10.1021/acsinfecdis.8b00319

 

 

32. Is synergy the key to treating high-density infections?

Pletzer D, Hancock REW. 

Future Microbiol. 13:1629-1632 

 

 

31. Liposomal therapy attenuates dermonecrosis induced by community-associated methicillin-resistant Staphylococcus aureus by targeting alpha-type phenol-soluble modulins and alpha-hemolysin.

Wolfmeier H, Mansour SC, Liu LT, Pletzer D, Draeger A, Babiychuk EB, Hancock REW. 

EBioMedicine. 33:211-217 

 

 

30. Synergy between conventional antibiotics and antibiofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens.

Pletzer D, Mansour SC, Hancock REW. 

PLoS Pathog. 14(6):e1007084 

 

 

29. Helicobacter pylori biofilm formation is differentially affected by common culture conditions, and proteins play a central role in the biofilm matrix.

Windham IH, Servetas SL, Whitmire JM, Pletzer D, Hancock REW, Merrell SD. 

Appl Environ Microbiol. 84(14). pii: e00391-18 

 

 

28. TonB-dependent receptor repertoire of Pseudomonas aeruginosafor uptake of siderophore-drug conjugates.

Luscher A, Moynie L, Auguste PS, Bumann D, Mazza L, Pletzer D, Naismith J, Koehler T.

Antimicrob Agents Chemother. 62(6). pii: e00097-18 

 

 

27. Impact of host defence peptides on chronic wounds and infections.

Haney EF*, Pletzer D*, Hancock REW. 

Title of book: Recent clinical techniques, results, and research in wounds. Springer. Cham. 1-17

 

 

2017

26. New perspectives in biofilm eradication.

Wolfmeier H*, Pletzer D*, Mansour SC*, Hancock REW. 

ACS Infect Dis. 4(2):93-106 

 

 

25. Synthetic peptides target stringent response-controlled virulence in a Pseudomonas aeruginosa murine cutaneous infection model.

Pletzer D, Wolfmeier H, Bains M, Hancock REW.

Front Microbiol. 8:1867 

 

 

24. Alternative strategies for the study and treatment of clinical bacterial biofilms.

Belanger C*, Mansour SC*, Pletzer D*, Hancock REW.

Emerg Top Life Sci. ETLS20160020 

 

 

23. Single residue acts as gate in OccK channels.

Pothula KR, Dhanasekar NN, Lamichhane U, Younas F, Pletzer D, Benz R, Winterhalter M, Kleinekathoefer U.

J Phys Chem B. 121(12):2614-2621 

 

 

22. New mouse model for chronic infections by Gram-negative bacteria enabling the study of anti-infective efficacy and host-microbe interactions.

Pletzer D, Mansour SC, Rahanjam N, Wuerth K, Hancock REW.

mBio. 8(1). pii: e00140-17 

 

 

21. Structure and function of the PiuA and PirA siderophore-drug receptors from P. aeruginosa and A. baumannii.

Moynie L, Luscher A, Rolo D, Pletzer D, Tortajada A, Weingart H, Braun Y, Page MG, Naismith JH, Koehler T.

Antimicrob Agents Chemother. 61(4). pii: e02531-16 

 

 

20. Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic.

Chalhoub H, Pletzer D, Weingart H, Braun Y, Tunney MM, Elborn JS, Rodriguez-Villalobos H, Plesiat P, Kahl BC, Denis O, Winterhalter M, Tulkens PM, Van Bambeke F.

Sci Rep. 7:40208 

 

 

2016

19. The bacteriophage-derived transcriptional regulator, LscR, activates the expression of levansucrase genes in Pseudomonas syringae.

Abdallah K, Hartman K, Pletzer D, Zhurina D, Ullrich MS.

Mol Microbiol. 7:40208 

 

 

18. Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically.

Mansour S, Pletzer D, de la Fuente-Nunez C, Kim P, Cheung GY, Joo HS, Otto M, Hancock REW.

EBioMedicine. 7:40208 

 

 

17. Antibiofilm peptides: Potential as broad-spectrum agents.

Pletzer D, Hancock REW. 

J Bacteriol. 198(19):2572-2578 

 

 

16. Anti-biofilm peptides as a new weapon in antimicrobial warfare.

Pletzer D*, Coleman SR*, Hancock REW. 

Curr Opin Microbiol. 33:35-40 

 

 

15. Draft genome sequence of Dietza maris DSM 43672, a Gram-positive bacterium of Mycolata group.

Ganguly S, Jimenez-Galisteo G, Pletzer D, Winterhalter M, Benz R, Vienas M. 

Genome Announc. 4(3) 

 

 

14. Swarming motility is modulated by expression of the putative xenosiderophore transporter SppR-SppABCD in Pseudomonas aeruginosa PA14.

Pletzer D, Braun Y, Weingart H. 

Antonie Van Leeuwenhoek. 109(6):737-753 

 

 

2015

13. Marinobacter adhaerens HP15 harbors two CzcCBA efflux pumps involved in zinc detoxification.

Stahl A, Pletzer D, Mehmood A, Ullrich MS. 

Antonie Van Leeuwenhoek. 108(3):649-658 

 

 

12. The Pseudomonas aeruginosa PA14 ABC transporter NppA1A2BCD is required for uptake of peptidyl nucleoside antibiotics.

Pletzer D, Braun Y, Dubiley S, Lafon C, Koehler T, Page MG, Mourez M, Severinov K, Weingart H.

J Bacteriol. 197(13):2217-2228 

 

 

11. Expression of extra-cellular levansucrase in Pseudomonas syringae is controlled by the in planta fitness-promoting metabolic repressor HexR.

Mehmood A, Abdallah K, Khandekar S, Zhurina D, Srivastava A, Al-Karablieh N, Alfaro-Espinoza G, Pletzer D, Ullrich MS.

BMC Microbiol. 15:48 

 

 

10. Role of the cell envelope stress regulators BaeR and CpxR in control of RND-type multidrug efflux pumps and transcriptional cross talk with exopolysaccharide synthesis in Erwinia amylovora.

Pletzer D, Stahl A, Oja AE, Weingart H.

Arch Microbiol. 197(6):761-772 

 

 

2014

9. Identification, characterization, isolation and activity against Escherichia coli of quince (Cydonia oblonga) fruit polyphenols.

Elsadig Karar MG, Pletzer D, Jaiswal R, Weingart H, Kuhnert N.

Food Res Int.  Vol 65, Part A 121-129 

 

 

8. High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate binding proteins DppA1-A5 in Pseudomonas aeruginosa

Pletzer D, Lafon C, Braun Y, Koehler T, Page MG, Mourez M, Weingart H.

PLoS One. 9(10):e111311 

 

 

7. Enhanced expression of codon optimized Mycobacterium avium subsp. paratuberculosis antigens in Lactobacillus salivarius.

Johnston C, Bannantine JP, Govender R, Endersen L, Pletzer D, Weingart H, Coffey A, O’Mahony J, Sleator RD.

Front Cell Infect Microbiol. 4:120 

 

 

6. AraC/XylS family stress response regulators Rob, SoxS, PliA, and OpiA in the fire blight pathogen Erwinia amylovora.

Pletzer D, Schweizer G, Weingart H.

J Bacteriol. 196:3098-3110 

 

 

5. Characterization and regulation of the Resistance-Nodulation-Cell Division-type multidrug efflux pumps MdtABC and MdtUVW from the fire blight pathogen Erwinia amylovora.

Pletzer D, Weingart H.

BMC Microbiol. 14:185 

 

 

4. The conserved upstream region of lscB/C determines expression of different levansucrase genes in plant pathogen Pseudomonas syringae.

Khandekar S, Srivastava A, Pletzer D, Stahl A, Ullrich MS.

BMC Microbiol. 14:79 

 

 

3. Characterization of AcrD, a Resistance Nodulation-Cell Division-type multidrug efflux pump from the fire blight pathogen Erwinia amylovora.

Pletzer D, Weingart H.

BMC Microbiol. 14:13

 

 

2013

2. Codon optimisation to improve expression of a MAP-specific membrane-associated antigen by Lactobacillus salivarius.

Johnston C, Douarre PE, Soulimane T, Pletzer D, Weingart H, MacSharry J, Coffey A, Sleator, RD, O’Mahony J.

Pathog Dis. 68:27-38 

 

 

2009

1. Phylogenetic detection of horizontal gene transfer during the step-wise genesis of Mycobacterium tuberculosis.

Veyrier F, Pletzer D, Turenne C, Behr MA.

BMC Evol Biol. 9:196