A detailed understanding of the mechanisms of complex polymicrobial infections are still lacking. Therefore, we strive to shed light on these biological processes by studying polymicrobial communities in vitro and polymicrobial infections in vivo. In the lab, we specifically focus on biofilm and persistence of Gram-positive Staphylococcus, Streptococcus, Enterococcus, and Propionibacterium as well as Gram-negative Pseudomonas, Klebsiella and Acinetobacter. In relation to human disease, we work on the exploration of a novel polymicrobial murine skin abscess infection model to study inter- and host-pathogen interactions.
First-order protein-protein interaction network of the host response during chronic P. aeruginosa skin infection.
The use of cutting-edge fluorescent- and luminescent-based live imaging technologies allows us to study infection dynamics and disease progression of polymicrobial infections. When coupled with high-throughput sequencing technologies, we are able to get a detailed view of both host and pathogen responses during infection. We use RNA-Seq and Tn-Seq (transposon insertion sequencing) to investigate the transcriptome and essential genes that contribute to inter- and host-pathogen interactions. Our research also seeks to discover new disease-causing factors to understand why host defense mechanisms fail against certain infections.
Other research projects: